Tuesday, December 11, 2012



Phentermine is an appetite suppressant that was approved by the FDA in 1959 for short-term  treatment  of obesity. Phen- termine stimulates a group of neurotransmitters known as catecholamines, which signal a flight-or-fight response in the body.
It is believed that the brain does not receive the hunger signal because it is receiving the fight-or-flight signal and focusing on the immediate need for energy. It is also believed that phentermine  increases the level of the hormone  leptin, which signals the body to feel full.
In addition to increasing hormones  that make a person feel full, phentermine also inhibits another neurotransmitter, neuropeptide Y. This neurotransmitter  signals the body to eat, decrease physical activity, and increase fat storage. The combi- nation of making a person feel full, increasing the desire to be more physically active, and inhibiting hunger and fat storage made phentermine seem like a great combination.
Like many of the first weight-loss drugs, phentermine is meant for short-term use, generally no longer than six months. Most users of phentermine can expect to see one-half to one pound of weight loss per week. One study of 24 weeks showed that phentermine users lost 22 pounds compared to 10 pounds of weight loss by people receiving a placebo. During the experi- ment, all participants were given an individualized diet, which explains why the people taking the placebo lost weight.1 The idea is that once a person gets a jump start on weight loss from the drug, he or she would feel motivated to maintain the loss or ideally lose more through diet and exercise. The long- term effects of phentermine are unknown.
Phentermine is most notorious for its potentially fatal interaction  with two other  weight-loss drugs, fenfluramine
(Fen-phen) and dexfenfluramine (Redux), which can cause a rare lung disorder called pulmonary hypertension as well as heart valve disease. When phentermine is used alone, however, this danger appears to be absent; for this reason, this drug continues to be sold under the brand names Adipex-P, Fastin, Obenix, Phentercot, Pro-Fast, and Teramine. Users of phen- termine are warned by the manufacturer about this dangerous interaction with fenfluramine and dexfenfluramine.

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